Francesco G. Salituro: search on Z-Library

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1

Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1 H -pyrazol-1′-yl)-19-nor-5β- pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid) A Receptor

Martinez Botella, Gabriel, Salituro, Francesco G., Harrison, Boyd L., Beresis, Richard T., Bai, Zhu, Blanco, Maria-Jesus, Belfort, Gabriel M., Dai, Jing, Loya, Carlos M., Ackley, Michael A, Althaus, A

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 570 KB

english, 2017

2

Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1-Mutant Cancers

Popovici-Muller, Janeta, Lemieux, René M., Artin, Erin, Saunders, Jeffrey O., Salituro, Francesco G., Travins, Jeremy, Cianchetta, Giovanni, Cai, Zhenwei, Zhou, Ding, Cui, Dawei, Chen, Ping, Straley,

Journal:

ACS Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 429 KB

english, 2018

3

Design, synthesis and molecular modeling of 3-acylamino-2- Carboxyindole NMDA receptor glycine-site antagonists

Francesco G. Salituro, Ronald C. Tomlinson, Bruce M. Baron, David A. Demeter, Herschel J.R. Weintraub, Ian A. McDonald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1991

Language:

english

File:

PDF, 367 KB

english, 1991

4

Synthetic and enzyme inhibition studies of pepstatin analogs containing hydroxyethylene and ketomethylene dipeptide isosteres

Holladay, Mark W., Salituro, Francesco G., Rich, Daniel H.

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 1.47 MB

english, 1987

5

ChemInform Abstract: Design and Synthesis of Novel Conformationally Restricted HIV Protease Inhibitors.

Francesco G. Salituro, ET AL. ET AL.

Journal:

Year:

1999

File:

PDF, 32 KB

1999

6

Corrigendum to “A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors” [Bioorg. Med. Chem. Lett. 20 (2010) 153]

Tiansheng Wang, Mark W. Ledeboer, John P. Duffy, Francesco G. Salituro, Albert C. Pierce, Harmon J. Zuccola, Eric Block, Dina Shlyakter, James K. Hogan, Youssef L. Bennani

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 104 KB

english, 2010

7

Inhibition of aspartic proteinases by peptides containing lysine and ornithine side-chain analogs of statine

Salituro, Francesco G., Agarwal, Nirankar, Hofmann, Theo, Rich, Daniel H.

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 1.34 MB

english, 1987

8

MDL 100,458 and MDL 102,288: two potent and selective glycine receptor antagonists with different functional profiles

John H. Kehne, Bruce M. Baron, Boyd L. Harrison, Timothy C. McCloskey, Michael G. Palfreyman, Matthieu Poirot, Francesco G. Salituro, Barry W. Siegel, Amy L. Slone, Paul L.M. Van Giersbergen, H.Steven

Journal:

European Journal of Pharmacology

Year:

1995

Language:

english

File:

PDF, 924 KB

english, 1995

9

The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor

Duffy, John P., Harrington, Edmund M., Salituro, Francesco G., Cochran, John E., Green, Jeremy, Gao, Huai, Bemis, Guy W., Evindar, Ghotas, Galullo, Vincent P., Ford, Pamella J., Germann, Ursula A., Wi

Journal:

ACS Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.84 MB

english, 2011

10

2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2

Mark W. Ledeboer, Albert C. Pierce, John P. Duffy, Huai Gao, David Messersmith, Francesco G. Salituro, Suganthini Nanthakumar, Jon Come, Harmon J. Zuccola, Lora Swenson, Dina Shlyakter, Sudipta Mahaja

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.98 MB

english, 2009

11

Inhibition of aspartic proteases by pepstatin and 3-methylstatine derivatives of pepstatin. Evidence for collected-substrate enzyme inhibition

Rich, Daniel H., Bernatowicz, Michael S., Agarwal, Nirankar S., Kawai, Megumi, Salituro, Francesco G., Schmidt, Paul G.

Journal:

Year:

1985

Language:

english

File:

PDF, 1.10 MB

english, 1985

12

Synthesis of analogs of pepstatin. Effect of structure in subsites P1', P2', and P2 on inhibition of porcine pepsin

Rich, Daniel H., Salituro, Francesco G.

Journal:

Journal of Medicinal Chemistry

Year:

1983

Language:

english

File:

PDF, 1.04 MB

english, 1983

13

Enzyme-Activated Antagonists of the Strychnine-Insensitive Glycine/NMDA Receptor

Salituro, Francesco G., Tomlinson, Ronald C., Baron, Bruce M., Palfreyman, Michael G., McDonald, Ian A., Schmidt, Werner, Wu, Hui Qiu, Guidetti, Paolo, Schwarcz, Robert

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 381 KB

english, 1994

14

3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the NMDA (N-methyl-D-aspartic acid) receptor associated glycine binding site

Salituro, Francesco G., Harrison, Boyd L., Baron, Bruce M., Nyce, Philip L., Stewart, Kenneth T., Kehne, John H., White, H. Steven, McDonald, Ian A.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 1.23 MB

english, 1992

15

Rescue of deficient amygdala tonic γ-aminobutyric acidergic currents in the Fmr -/y mouse model of fragile X syndrome by a novel γ-aminobutyric acid type A receptor-positive allosteric modulator

Martin, Brandon S., Martinez-Botella, Gabriel, Loya, Carlos M., Salituro, Francesco G., Robichaud, Albert J., Huntsman, Molly M., Ackley, Mike A., Doherty, James J., Corbin, Joshua G.

Journal:

Journal of Neuroscience Research

Year:

2016

Language:

english

File:

PDF, 502 KB

english, 2016

16

Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo

Popovici-Muller, Janeta, Saunders, Jeffrey O., Salituro, Francesco G., Travins, Jeremy M., Yan, Shunqi, Zhao, Fang, Gross, Stefan, Dang, Lenny, Yen, Katharine E., Yang, Hua, Straley, Kimberly S., Jin,

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 982 KB

english, 2012

17

Breakthroughs in Neuroactive Steroid Drug Discovery

Blanco, Maria-Jesus, La, Daniel, Coughlin, Quinn, Newman, Caitlin, Griffin, Andrew, Harrison, Boyd L., Salituro, Francesco G.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 1.05 MB

english, 2017

18

[125I]Iododesethyl tamoxifen aziridine: Synthesis and covalent labeling of the estrogen receptor with an iodine-labeled affinity label

Francesco G. Salituro, Kathryn E. Carlson, Jonathan F. Elliston, Benita S. Katzenellenbogen, John A. Katzenellenbogen

Journal:

Year:

1986

Language:

english

File:

PDF, 1.71 MB

english, 1986

19

Highly sensitive assays for proteinases using immobilized luminogenic substrates

Bruce R. Branchini, Francesco G. Salituro, Jeffrey D. Hermes, Nancy J. Post

Journal:

Biochemical and Biophysical Research Communications

Year:

1980

Language:

english

File:

PDF, 319 KB

english, 1980

20

Depletion of estrogen receptor in human breast tumor cells by a novel substituted indole that does not bind to the hormone binding domain

Bitonti, Alan J., Dumont, Jennifer A., Salituro, Francesco G., McDonald, Ian A., Jarvi, Esa T., Frey, Lisa M., Wright, Paul S., Baumann, Russell J.

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

1996

Language:

english

File:

PDF, 1.16 MB

english, 1996

21

Multisubstrate Inhibition of 4-Hydroxybenzoate 3-Monooxygenase

Salituro, Francesco G., Demeter, David A., Weintraub, Herschel J. R., Lippert, Bruce J., Resvick, Robert J., McDonald, Ian A.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 323 KB

english, 1994

22

ChemInform Abstract: Novel Inhibitors of HIV Protease: Design, Synthesis and Biological Evaluation of Picomolar Inhibitors Containing Cyclic P1/P2 Scaffolds.

Andrew Spaltenstein, Merrick R. Almond, William J. Bock, Darryl G. Cleary, Eric S. Furfine, Richard J. Hazen, Wieslaw M. Kazmierski, Francesco G. Salituro, Roger D. Tung, Lois L. Wright

Journal:

Year:

2000

File:

PDF, 29 KB

2000

23

Identification of oxygen nucleophiles in tetrahedral intermediates: 2H and 18O induced isotope shifts in 13C NMR spectra of pepsin-bound peptide ketone pseudosubstrates

Paul G. Schmidt, Mark W. Holladay, Francesco G. Salituro, Daniel H. Rich

Journal:

Biochemical and Biophysical Research Communications

Year:

1985

Language:

english

File:

PDF, 337 KB

english, 1985

24

Neuroactive Steroids. 1. Positive Allosteric Modulators of the (γ-Aminobutyric Acid) A Receptor: Structure–Activity Relationships of Heterocyclic Substitution at C-21

Martinez Botella, Gabriel, Salituro, Francesco G., Harrison, Boyd L., Beresis, Richard T., Bai, Zhu, Shen, Kaisheng, Belfort, Gabriel M., Loya, Carlos M., Ackley, Michael A., Grossman, Scott J., Hoffm

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 555 KB

english, 2015

25

ChemInform Abstract: Design, Synthesis, and Conformational Analysis of a Novel Series of HIV Protease Inhibitors.

Francesco G. Salituro, ET AL. ET AL.

Journal:

Year:

1999

File:

PDF, 27 KB

1999

26

Design, synthesis, and conformational analysis of a novel series of HIV protease inhibitors

Christopher T. Baker, Francesco G. Salituro, John J. Court, David D. Deininger, Eunice E. Kim, Biquin Li, Perry M. Novak, Bhisetti G. Rao, S. Pazhanisamy, Wayne C. Schairer, Roger D. Tung

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 305 KB

english, 1998

27

Anticonvulsant profile of the neuroactive steroid, SGE-516, in animal models

Hammond, Rebecca S., Althaus, Alison L., Ackley, Michael A., Maciag, Carla, Martinez-Botella, Gabriel, Salituro, Francesco G., Robichaud, Albert J., Doherty, James J.

Journal:

Epilepsy Research

Year:

2017

Language:

english

File:

PDF, 1.58 MB

english, 2017

28

Design and synthesis of novel conformationally restricted HIV protease inhibitors

Francesco G. Salituro, Christopher T. Baker, John J. Court, David D. Deininger, Eunice E. Kim, Biquin Li, Perry M. Novak, Bhisetti G. Rao, S. Pazhanisamy, Margaret D. Porter, Wayne C. Schairer, Roger

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 293 KB

english, 1998

29

Enzyme-catalyzed production of the neuroprotective NMDA receptor antagonist 7-chlorokynurenic acid in the rat brain in vivo

Hui-Qiu Wu, Francesco G. Salituro, Robert Schwarcz

Journal:

European Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 1.04 MB

english, 1997

30

Impact of allosteric modulation in drug discovery: innovation in emerging chemical modalities

Han, Bingsong, Salituro, Francesco G., Blanco, Maria-Jesus

Journal:

ACS Medicinal Chemistry Letters

Year:

2020

File:

PDF, 329 KB

2020

31

ChemInform Abstract: Inhibitors of p38 MAP Kinase: Therapeutic Intervention in Cytokine-Mediated Diseases

Francesco G. Salituro, Ursula A. Germann, Keith P. Wilson, Guy W. Bemis, Ted Fox, Michael S.-S. Su

Journal:

Year:

1999

File:

PDF, 27 KB

1999

32

Dual p38/JNK Mitogen Activated Protein Kinase Inhibitors Prevent Ozone-Induced Airway Hyperreactivity in Guinea Pigs

Verhein, Kirsten C., Salituro, Francesco G., Ledeboer, Mark W., Fryer, Allison D., Jacoby, David B., Fehrenbach, Heinz

Journal:

Year:

2013

Language:

english

File:

PDF, 728 KB

english, 2013

33

Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator

Althaus, Alison L., Ackley, Michael A., Belfort, Gabriel M., Gee, Steven M., Dai, Jing, Nguyen, David P., Kazdoba, Tatiana M., Modgil, Amit, Davies, Paul A., Moss, Stephen J., Salituro, Francesco G.,

Journal:

Neuropharmacology

Year:

2020

File:

PDF, 2.44 MB

2020

34

Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors

Jingrong Cao, Huai Gao, Guy Bemis, Francesco Salituro, Mark Ledeboer, Edmund Harrington, Susanne Wilke, Paul Taslimi, S. Pazhanisamy, Xiaoling Xie, Marc Jacobs, Jeremy Green

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 857 KB

english, 2009

35

Facile synthesis of L-kynurenine

Salituro, Francesco G., McDonald, Ian A.

Journal:

Journal of Organic Chemistry

Year:

1988

Language:

english

File:

PDF, 289 KB

english, 1988

36

Novel inhibitors of HIV protease: design, synthesis and biological evaluation of picomolar inhibitors containing cyclic P1/P2 scaffolds

Andrew Spaltenstein, Merrick R Almond, William J Bock, Darryl G Cleary, Eric S Furfine, Richard J Hazen, Wieslaw M Kazmierski, Francesco G Salituro, Roger D Tung, Lois L Wright

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 152 KB

english, 2000

37

3-(2-Carboxyindol-3-yl)propionic acid derivatives: antagonists of the strychnine-insensitive glycine receptor associated with the N-methyl-D-aspartate receptor complex

Salituro, Francesco G., Harrison, Boyd L., Baron, Bruce M., Nyce, Philip L., Stewart, Kenneth T., McDonald, Ian A.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 406 KB

english, 1990

38

Janus Kinase 2 Inhibitors. Synthesis and Characterization of a Novel Polycyclic Azaindole

Wang, Tiansheng, Duffy, John P., Wang, Jian, Halas, Summer, Salituro, Francesco G., Pierce, Albert C., Zuccola, Harmon J., Black, James R., Hogan, James K., Jepson, Scott, Shlyakter, Dina, Mahajan, Su

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.36 MB

english, 2009

39

Neuroactive Steroid N-Methyl-D-aspartate Receptor (NMDAR) Positive Allosteric Modulators: Synthesis, SAR and Pharmacological Activity

La, Daniel S., Salituro, Francesco G., Martinez Botella, Gabriel, Griffin, Andrew, Bai, Zhu, Ackley, Michael, Dai, Jing, Doherty, James, Harrison, Boyd, Hoffman, Ethan, Kazdoba, Tatiana, Lewis, Michae

Journal:

Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 625 KB

english, 2019

40

Sensitive enzyme assays based on the production of chemiluminescent leaving groups

Bruce R. Branchini, Jeffrey D. Hermes, Francesco G. Salituro, Nancy J. Post, Göran Claeson

Journal:

Analytical Biochemistry

Year:

1981

Language:

english

File:

PDF, 805 KB

english, 1981

41

Pepsin-catalysed addition of water to a ketomethylene peptide isostere: observation of the tetrahedral species by 13 C-nuclear-magnetic-resonance spectroscopy

HOLLADAY, MARK W., SALITURO, FRANCESCO G., SCHMIDT, PAUL G., RICH, DANIEL H.

Journal:

Biochemical Society Transactions

Year:

1985

Language:

english

File:

PDF, 299 KB

english, 1985

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